E621
Monosodium glutamate (MSG)
Also known as: MSG, Sodium glutamate, Umami seasoning
Components / composition
Sodium salt of L-glutamic acid (one sodium ion per glutamate).
Common usage in food
Flavor enhancer in soups, snacks, ready meals, and seasonings.
Effects on human health
Provides umami taste. Metabolized as dietary glutamate. Blood glutamate levels tightly regulated.
Risks & considerations
Large single doses (>3 g without food) may cause transient headache or flushing in sensitive individuals. Typical dietary exposure much lower.
Regulatory approval (EU)
Permitted in EU Annex II with category-specific limits.
US regulatory status (FDA)
Monosodium glutamate (MSG) is GRAS in the U.S. and widely used as a flavor enhancer in savory foods. FDA classifies MSG as generally recognized as safe, and the glutamate in MSG is chemically indistinguishable from glutamate naturally present in foods. The EU sets category-specific maximum levels; the U.S. relies on GMP under GRAS.
Permitted amounts / regulatory limits (EU)
Maximum levels per food category in Annex II Part E (e.g., 10 g/kg in some savory foods).
Acceptable Daily Intake (ADI)
Not allocated (JECFA: acceptable at customary use levels).